It is a group of hereditary disorders in the blood that results in the synthesis of hemoglobin molecules with abnormal structure (CDC, 2014). It arises due to the substitution (Hb S and Hb C), deletion (Hb Gun Hill), hybridization (Hb Lepore) or elongation (Hb Constant Spring) of amino acids in the DNA sequence (Uthman, n.d). This group of single-gene disorders is commonly found in the Mediterranean, Southeast Asian and African populations. Approximately, 7% of the world’s population are carriers, meaning, they carry the abnormal gene but do not experience pathologic effects.
The most common and most clinically relevant Continue reading...