Obesity and Diabetes
1. “Explain why parabiosis of a lean control and an ob/ob mouse caused partial normalization of the body weight in ob/ob mutant mouse?”
The parabiosis of an ob/ob mouse and lean mouse results in:
Increase weight gain in ob/ob mouse
Decrease food uptake of pair
Increase survival of pair for months
The above mentioned effects appear due to the production of a factor named as Leptin that is produced by normal mouse but in a very low concentration that is not sufficient for the body. The ob/ob mouse has receptors to attach this factor but as the amount of leptin is very low, as compared to db/db mutant mouse, it Continue reading...