Pathway Essays Samples That Help You Write Better, Faster & with Gusto

Critical appraisal of “Co-localization of β-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation”
The increasing prevalence of colorectal cancer among Asians has been attributed to the westernization of their diet. The title of the article explicitly mentions the population, parameter and the expected outcome of the study. According to the authors, the protein β-catenin has been previously observed to localize in the sub-cellular regions followed by translocation to the nucleus. The authors believe that this step promotes the immortalization of the cells, thereby establishing the relevance of Continue reading...

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Figure 1: Down regulation of XIAP by specific inhibitor Embelin inhibits cell viability in a dose dependent manner. Investigation was conducted to determine the role of XIAP in the pathogenesis of BC and the impact of its down regulation in the inhibition of BC cell viability. Fig. 1 showed that all cell lines (CAL120, EVSAT, MCF7, and MDAMB231) experienced enormous drop to <40% in mean cell viability at 50μm, with least outcome variability found in EVSAT cell line, indicating dose-dependent vulnerability to Embelin action. Although the MCF7 cell line averaged < Continue reading...

Graph theory is a modern mathematical theory about applications and properties of graphs. A graph is made of vertices connected to each other using lines called edges. A graph helps us describe the interrelationship between related objects. Graphs are mathematical structures that act as models to many types of relations (Novak & Gibbons, 2009). They represent many practical problems and have a variety of uses in various fields, for example, their use in physics and chemistry to study molecules. In mathematics they help in the study of geometry. They have also contributed much in the area of networking such as Continue reading...

Introduction

Diabetes mellitus is a serious metabolic disorder, with a complex of symptoms, such as hyperglycemia, as a result of dysfunction in producing of the insulin, its synthesis or secretion. (Stöppler, 2014). This disease may lead to serious complications. The major risk factors that raise the prevalence of diabetes are hypertension, obesity, pressed immune resistance to the infectious illnesses and even cancer. (Bilous, 2002.) Patients with diabetes are more probable to develop neuropathic vascular diseases (National Diabetes Education Program NDEP 2000). In 2010 there were 66,702 registered cases of diabetes in Oman (Oman Ministry of Health 2010) and Continue reading...

There are several hypotheses and theories that suggest that the occurrence of maternal obesity has adverse outcomes for the offspring’s health in the later life. Human and animal studies have shown evidence that indicate that obesity in mothers increases the offspring’s risk of developing obesity. With the varied evidence, it is necessary for maternal obesity is curbed in the bud to lower the risk of offspring becoming obese in their later lives.
Maternal obesity or excessive maternal nutrition may lead to obesity and obesity-related disease in offspring later in life. Overweight or obesity is an accumulation of Continue reading...

Diabetes Care and Management

Introduction
Diabetes is a chronic ailment caused by the diminished effectiveness or deficient production of the hormone insulin in the body. The characteristics of the disease include the presence of sugar glucose in blood at levels that are abnormally high. The disease reveals itself in complex symptoms such as hyperglycemia as a result of the pancreas not producing enough insulin or poor synthesis of 1secreted insulin in the body (Stoppler, 2014). This disease may lead to serious complications that include eye disease, nerve disease, kidney disease, dental problems, heart disease, and high blood pressure. The major risk factors that Continue reading...

Cardiovascular Quiz

Q1. What is the advantage of SELDI-TOF-MS based assays over conventional methods?
Surface-enhanced laser desorption/ionization time of flight (SELDI-TOF) mass spectrometry (MS) is advantageous over conventional methods as it can use endogenous synthetic substrates. Moreover, it has the ability to directly determine enzymatic peptide products. It is also a rapid, reproducible and sensitive method for the analysis of enzymatic activities of renin–angiotensin system (RAS).

Q2. What is the difference between carboxy peptidases and endopeptidases?

Carboxypeptidases are exopeptidases that are used to cleave (hydrolyze) amino acid residues from the carboxy-terminal (C-terminal) portion of proteins, whereas endopeptidases cleave amino acids from the nonterminal portion of proteins.

Q3. What are the biological activities of Ang (1-9) and Ang (1-7)?

Ang I cleavage results Continue reading...

The Way, or Taoism, is a world-renowned method of living one’s life. Often confused with a simple and peaceful way of living, the religions of the world that have adopted Taoism or, the Way, have many intricate philosophical and ethical origins followers are expected to abide by. Confucianists and Daoists are two groups that have adopted the Way, using it to navigate the perils of the mortal world. It meant different things to each group, and they followed it for different reasons in an effort to make sense of themselves and the world around them.
Confucianists interpreted the Continue reading...