Critical appraisal of “Co-localization of β-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation”
The increasing prevalence of colorectal cancer among Asians has been attributed to the westernization of their diet. The title of the article explicitly mentions the population, parameter and the expected outcome of the study. According to the authors, the protein β-catenin has been previously observed to localize in the sub-cellular regions followed by translocation to the nucleus. The authors believe that this step promotes the immortalization of the cells, thereby establishing the relevance of
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