The Diastolic Dysfunction
Introduction
Diastolic dysfunction is characterised by mechanical abnormalities attributing to defects in cardiac diastole. Clinically, diastole refers to the tenure in which myocardium expands and looses the potential of exerting force leading to the cardiac output. However, the diastolic dysfunction is the direct outcome of the insufficiency of diastolic processes, as evidenced by the clinical literature. The cardiac diastole includes the isovolumetric relaxation resulting in cardiac filling through the active and passive mechanisms. Indeed, the systematic reduction in ventricular pressure is the outcome of myocardial relaxation governed by uncoupling between actin and myosin cross bridges and transfer of calcium
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