Sample Essay On The Main Uses Of Carbimazole In Clinical Practice And The Evidence Base Of This

According to Cohen et al. (2010), Carbimazole is the most common use of medicine used while diagnosing overactive thyroid (or hyperthyroidism). The most widely used antithyroid medicine in the United Kingdom (UK) is known as carbimazole, which is followed by propylthiouracil. Propylthiouracil and Carbimazole belong to a class of medicines known as thionamides. Thionamides produces similar reactions in the thyroid gland.
Thyroxine is also known as T4: this is a body hormone that is produced by the thyroid gland. It is transmitted round the body in the bloodstream. It allows maintaining the body's functions at an accurate pace. Different tissues and cells in the body require the thyroxine to keep them working at a correct pace. Carbimazole treatment is the most frequently used as a long-term treatment for hyperthyroidism caused due to Graves’ disease, (Franklyn et al. 2005). However, it can be used to differentiate a monitoring test that is used for diagnosis within healthcare, (Ceresini et al. 2009).
In United Kingdom (UK), it is a common clinical practice to start drug therapy of hyperthyroid Graves’ disease with 40mg daily with carbimazole. According to the clinical evidence-based research, it indicates that carbimazole may cause a sudden fall in the white blood cell count in a lesser amount of patients within the first five months of treatment. This is considered as undeniably and clinically harmful effects of treatment when a straightforward treatment test or a full blood count is in place, (Hjorland, 2011).

Evidence based practice

Meta-analysis indicates that there is prevalence of rash during antithyroid drug trials, (Hjorland, 2011; Ceresini et al. 2009; Patterson et al. 2012).

References

CeresiniG, Lauretani F, Maggio M, et al. (2009). Thyroid func-tion abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. J Am Geriatr Soc.57:89-93.
Cohen-Lehman J, Dahl P, Danzi S, Klein I (2010) Effects of amiodarone therapy on thyroid function. Nat RevEndocrinology.6:34-41.
Franklyn JA, Sheppard MC & Maisonneuve P. (2005) Thyroid function andmortality in patients treated for hyperthyroidism.Journal of theAmerican Medical Association. 29471–80.
Hjorland, Birger (2011). Evidence based practice: An analysis based on the philosophy of science. Journal of the American Society for Information Science and Technology62 (7): 1301–10.
Patterson-Silver Wolf, D.A.; Dulmus, C.N.; Maguin, E. (2012).Empirically supported treatment’s impact on organizational culture and climate.Research on Social Work Practice22 (6): 665–671