Good Example Of Essay On Glaxo Smith Kline

Type of paper: Essay

Topic: Drugs, Candidate, Science, Reward, Elections, Development, Discovery, Company

Pages: 2

Words: 550

Published: 2020/11/19

Before merging, the process of discovering drugs at GSK, as well as SKB, had similarities based on the industry standards. It ran in an order, respectively to Pre-discovery Research is the initial stage to identify the target of the drug through screening for bind ability with the target. Which was followed by Lead optimization, the lead was tried against various animal disease models considering numerous features such as the extent of the activity.
The Preclinical evaluation followed for only prospective drugs. It entailed consideration of toxicity and its effectiveness against more detail-oriented model diseases. After that, it ran in phases with respect to the order of phase I, phase II, and phase III. After the phases, it went through the FDA for filing and approval. The phase mode involved first time in human, how to administer the drug, safety in healthy individuals and finally on targeted humans.
The shortcomings of the old approach were between discovery and the development phase, 90% of the drugs got dropped out because they had no proof of concept. The main cause of this problem was the incentive in the form of reward to the scientists. The reward based on the efficaciousness of the candidate compounds, therefore dropping the development part of the process because perhaps the scientist did not achieve the reward. The shortcoming was after the failure the scientists never tried on to develop the candidate and determine what it can do. In doing so, the scientists limited the success of the cures even before succeeding to identify what it can achieve as a medical cure during the established tests. I believe that the problem was as Yamada discovered it.
The underlying philosophical guide used by Yamada in restructuring R and D is he identified the problem, which was that 90 % of the candidate compounds never made it to the development stage. From that point, he empowered pharmaceutical firms affiliated to GSK to empower their drug discovery. In the early stages and for the large firms he strengthened their development processes featuring the clinical trials, coming forward to the FDA approvals of the candidate compounds.
Because of the empowerment of smaller firms the compounds that were marketable were enabled to reach the market. The establishment of the centers for drug discovery became the backbone for classified and specialized research centers that were reliable for targeting, identification and lead processes respectively. The CEDDS remained assigned to different specialized CEDDs and more autonomous reassignment to advanced stages that would ensure conversion from compound to manufactured medical goods.
Yamada came up with the best incentive to get the Scientists to work through with their discovered compounds. He granted them research ownership so that if they managed to get a compound candidate through to Proof of concept, then the reward would go directly to their contribution to the larger GSK Company. If the compound made it to the market, then the more reward, the scientist would get because that meant that the reward increases in the sales. The competitive nature of the medicine market gave Yamada the edge of innovation towards the successful discovery of the compounds to the development of the candidate compound onwards to the success proving of concept. Eventually, the sales bring more returns and more rewards.

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